Bussone G, Boiardi A, La Mantia L, Frediani F, Vescovi A, Parati E A
Cephalalgia. 1983 Aug;3 Suppl 1:163-7. doi: 10.1177/03331024830030S127.
The possible interaction between long-acting ergot and the opiate system has been studied in 12 migraine patients, evaluating the PRL releasing effect of morphine. Our data suggest the integrity of the opiate system in migraine patients and demonstrate that long-acting ergot does not interact with the dopaminergic system. We hypothesize that the effect of ergot on migraine pain may be related to the interaction with non-opiate substances with central analgesic action. Chronic treatment with long-acting ergot significantly reduces the peak of pain intensity of the migraine attack.
在12名偏头痛患者中研究了长效麦角与阿片系统之间可能的相互作用，评估了吗啡对催乳素释放的影响。我们的数据表明偏头痛患者阿片系统的完整性，并证明长效麦角不与多巴胺能系统相互作用。我们推测麦角对偏头痛疼痛的作用可能与与具有中枢镇痛作用的非阿片类物质相互作用有关。长期使用长效麦角治疗可显著降低偏头痛发作时疼痛强度的峰值。
