Lynn T C, Hsieh R P, Chuang C Y, Hsu M M, Hsieh T, Tu S M
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1983 May;16(2):41-8.
Serological and biochemical studies were done at the National Taiwan University Hospital, on 243 patients with biopsy-proved anaplastic nasopharyngeal carcinoma (NPC) in various clinical conditions. The remarkable elevation of both IgG and IgA antibody titers against EB virus was specific for NPC patients. The seropositive rates ranged from 75% to 100% in various stages of NPC patients. Serum IgG and IgA levels were also increased moderately and nonspecifically in stages II-IV and recurrent patients. Peripheral white blood cell count was also slightly increased in these patients. Peripheral lymphocyte counts were slightly decreased in patients with neck recurrence or distant metastasis. Serum IgM, C3, C4 and Acid phosphatase levels were within normal range in all the patients. Serum GOT, GPT, alkaline phosphatase, and lactate dehydrogenase were elevated in some of patients with distant metastasis and in most of those with liver metastasis. Mucoprotein was elevated in about 10% of stage II-IV patients but in about 50% of patients with recurrent neck metastasis or distant metastasis. in conclusion, serological and biochemical examinations are important in the diagnosis of late stages and recurrence or metastasis of NPC.
在台湾大学医院对243例经活检证实为不同临床状况的间变性鼻咽癌（NPC）患者进行了血清学和生化研究。针对EB病毒的IgG和IgA抗体滴度显著升高是NPC患者的特异性表现。NPC患者各阶段的血清阳性率在75%至100%之间。在II - IV期患者和复发患者中，血清IgG和IgA水平也有中度且非特异性升高。这些患者的外周白细胞计数也略有增加。颈部复发或远处转移患者的外周淋巴细胞计数略有下降。所有患者的血清IgM、C3、C4和酸性磷酸酶水平均在正常范围内。部分远处转移患者以及大多数肝转移患者的血清谷草转氨酶（GOT）、谷丙转氨酶（GPT）、碱性磷酸酶和乳酸脱氢酶升高。约10%的II - IV期患者黏蛋白升高，但颈部复发或远处转移患者中约50%的患者黏蛋白升高。总之，血清学和生化检查对NPC晚期及复发或转移的诊断很重要。
