Lynn T C, Tu S M
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1984 Feb;17(1):1-10.
Clinical, serological and lymphocyte studies were done on 435 patients with biopsy proved anaplastic nasopharyngeal carcinoma (NPC) in various clinical status, at the National Taiwan University Hospital, from January 1980 through June 1983. Studies on 134 normal control were also done. Using immunofluorescent antibody method, seropsitive rates of the antibody titers against viral capsid antigens (VCA) and early antigens (EA) of Epstein-Barr (EB) virus were 70.8%-100% for anti-VCA/IgG titers (greater than or equal to 1:640), 81.0%-100% for anti-VCA/IgA titers (greater than or equal to 1:40), 66.7%-93.8% for anti-EA/IgG titers (greater than or equal to 1:160), and 40.0%-87.5% for anti-EA/IgA titers (greater than or equal to 1:40) in NPC patients with disease. They decreased to 10.5%-21.7% in remission patients. In contrast, they were less than 5% in the control. Mean total serum IgG and IgA levels were moderately increased to around 1,500 mg/dl and 300 mg/dl respectively, in all patients. The increase was most remarkable in patients with liver metastases. In control the values were 1,211 mg/dl and 223 mg/dl, respectively. Mean serum IgM, C3 and C4 amounts of NPC patients were not significantly different from those of the normal control, the latter were 129, 80.3 and 43.2 mg/dl, respectively. Serum acid phosphatase and calcium levels of NPC patients were all in the normal range of 0.1-2.0 BU/ml and 2.0-3.0 mmol/dl, respectively. Serum GOT, GPT, alkaline phosphatase, lactate dehydrogenase and mucoprotein were elevated either alone or in combination in some patients before treatment, in many patients with neck recurrence or distant metastases, but in all patients with liver metastases. Using monoclonal antibodies (Ortho Inc., U.S.A.) to define lymphocyte subsets, B lymphocytes comprised about 12% and T lymphocytes about 60% in the patients, whereas they were 11.9% and 73.1% in the control. The helper/suppressor ratio was 1.7 in the control and about 1.0 in NPC patients, and was only 0.8 in remission patients. The lack of correlation between the seropositive rates of anti-VCA antibodies and the helper/suppressor ratio might indicate different manifestations of humoral and cellular immunity in patients with NPC.
1980年1月至1983年6月，在台湾大学医院对435例经活检证实为不同临床分期的间变性鼻咽癌（NPC）患者进行了临床、血清学和淋巴细胞研究。同时也对134名正常对照者进行了研究。采用免疫荧光抗体法，NPC患者中抗爱泼斯坦-巴尔（EB）病毒衣壳抗原（VCA）和早期抗原（EA）抗体滴度的血清阳性率分别为：抗VCA/IgG滴度（大于或等于1:640）为70.8%-100%，抗VCA/IgA滴度（大于或等于1:40）为81.0%-100%，抗EA/IgG滴度（大于或等于1:160）为66.7%-93.8%，抗EA/IgA滴度（大于或等于1:40）为40.0%-87.5%。缓解期患者的这些阳性率降至10.5%-21.7%。相比之下，对照组的阳性率低于5%。所有患者的血清总IgG和IgA水平平均适度升高，分别约为1500mg/dl和300mg/dl。在有肝转移的患者中升高最为显著。对照组的值分别为1211mg/dl和223mg/dl。NPC患者的血清IgM、C3和C4含量与正常对照组无显著差异，后者分别为129、80.3和43.2mg/dl。NPC患者的血清酸性磷酸酶和钙水平均在正常范围内，分别为0.1-2.0BU/ml和2.0-3.0mmol/dl。部分患者在治疗前、许多颈部复发或远处转移的患者以及所有有肝转移的患者中，血清谷草转氨酶（GOT）、谷丙转氨酶（GPT）、碱性磷酸酶、乳酸脱氢酶和粘蛋白单独或联合升高。使用单克隆抗体（美国奥索公司）来确定淋巴细胞亚群，患者中B淋巴细胞约占12%，T淋巴细胞约占60%，而对照组中分别为11.9%和73.1%。辅助/抑制细胞比值在对照组中为1.7，在NPC患者中约为1.0，在缓解期患者中仅为0.8。抗VCA抗体血清阳性率与辅助/抑制细胞比值之间缺乏相关性，这可能表明NPC患者体液免疫和细胞免疫有不同表现。
