Roselle G A, Warth P
J Antimicrob Chemother. 1983 Aug;12(2):189-92. doi: 10.1093/jac/12.2.189.
Because in-vitro antifungal synergism has been shown between the imidazoles and 5-fluorocytosine, we have evaluated the accuracy of a standard disc diffusion assay for serum 5-fluorocytosine levels in the presence of ketoconazole. In the usual clinical concentrations, ketoconazole does not interfere with the determination of serum 5-fluorocytosine levels by this standard test.
由于咪唑类药物与5-氟胞嘧啶之间已显示出体外抗真菌协同作用,我们评估了在酮康唑存在的情况下,用于检测血清5-氟胞嘧啶水平的标准纸片扩散法的准确性。在通常的临床浓度下,酮康唑不会干扰通过该标准试验测定血清5-氟胞嘧啶水平。