Harrell L E, Davis J N
Neuroscience. 1985 Jun;15(2):359-69. doi: 10.1016/0306-4522(85)90218-0.
2-Deoxy-D-[3H]glucose autoradiography was employed to investigate the effects of acute cholinergic manipulations on hippocampal glucose metabolism. In general, manipulations designed to reduce cholinergic activity (medial septal ablation, atropine treatment) reduced hippocampal glucose metabolism. Maximal decrements were found in the terminal fields of the septohippocampal projection after medial septal lesions, while maximal deficits after atropine treatment correlated with muscarinic receptor binding. Electrical stimulation of the medial septum resulted in increased glucose utilization in some terminal fields of the septohippocampal projection and decreased utilization in the terminal fields of the perforant pathway. Our data clearly indicate that acute alterations in cholinergic activity can affect hippocampal glucose metabolism but the distribution, direction and degree of these changes is dependent on the specific treatment.
采用2-脱氧-D-[3H]葡萄糖放射自显影术来研究急性胆碱能操作对海马葡萄糖代谢的影响。一般来说，旨在降低胆碱能活性的操作（内侧隔核损毁、阿托品治疗）会降低海马葡萄糖代谢。内侧隔核损伤后，在隔海马投射的终末区域发现了最大程度的减少，而阿托品治疗后的最大缺陷与毒蕈碱受体结合相关。内侧隔核的电刺激导致隔海马投射的一些终末区域葡萄糖利用增加，而穿通通路终末区域的利用减少。我们的数据清楚地表明，胆碱能活性的急性改变会影响海马葡萄糖代谢，但这些变化的分布、方向和程度取决于具体的治疗方法。
