Julesz J, Lis M, Gutkowska J, Mizsei I, Genest J
J Steroid Biochem. 1983 Sep;19(3):1297-9. doi: 10.1016/0022-4731(83)90153-x.
Dexamethasone, aldosterone and spironolactone inhibited the release of immunoreactive corticotropin (ACTH) from primary culture of the rat anterior pituitary cells. The steroids inhibited only the ACTH release stimulated by Pitressin and not the basal ACTH release by non-stimulated cells. On a molar basis, aldosterone appears to be the most efficient inhibitor of ACTH release while the effect of spironolactone is similar to the effect of dexamethasone. Simultaneous incubation with aldosterone and spironolactone inhibited the ACTH release to the same extent as spironolactone alone. This indicates that aldosterone's effect on ACTH release is also inhibited by spironolactone at the pituitary level.
地塞米松、醛固酮和螺内酯抑制大鼠垂体前叶细胞原代培养物中免疫反应性促肾上腺皮质激素（ACTH）的释放。这些类固醇仅抑制垂体后叶素刺激的ACTH释放，而不抑制未受刺激细胞的基础ACTH释放。按摩尔计算，醛固酮似乎是ACTH释放最有效的抑制剂，而螺内酯的作用与地塞米松相似。醛固酮和螺内酯同时孵育对ACTH释放的抑制程度与单独使用螺内酯相同。这表明在垂体水平上，螺内酯也能抑制醛固酮对ACTH释放的作用。
