Clinical evaluation of cefotiam (CGP/14221) versus cephalothin in the treatment of urinary tract infections.

A study was carried out in 35 patients with urinary tract infections to compare the efficacy and tolerance of cefotiam and cephalothin. Patients received at random either 1 g cefotiam twice daily (19 patients) or 1 g cephalothin 4-times daily (16 patients) parenterally over a period of 10 days. Therapeutic efficacy was assessed mainly on disappearance of bacteriuria. Only 1 patient of those receiving cefotiam failed to respond and suffered a delayed relapse. Five patients failed to respond to cephalothin: in 3 of them bacteriuria persisted throughout treatment and there was relapse in the other 2 patients. The time for the disappearance of bacteriuria was significantly shorter in the cefotiam group.