Trudel J L, Senterman M K, Brown R A
Surgery. 1983 Oct;94(4):691-6.
Current epidemiologic and experimental data emphasize the importance of nutrition in colon carcinogenesis. The interactions between dietary fat and dietary fiber were studied in the dimethylhydrazine model for colon cancer. A strict pair-feeding system was developed, and rats were fed one of five semisynthetic diets containing various amounts and types of fat and fiber. The incidence and number of tumors per animal were increased in all fat-fed groups. Adding fiber to the diets provided either partial (polyunsaturated fat) or complete (saturated fat) protection against the deleterious effect of fat. The antagonism between fat and fiber and the clinical relevance of these data are discussed.
当前的流行病学和实验数据强调了营养在结肠癌发生过程中的重要性。在二甲基肼诱导的结肠癌模型中，对膳食脂肪与膳食纤维之间的相互作用进行了研究。建立了严格的配对喂养系统，给大鼠喂食五种半合成饮食中的一种，这些饮食含有不同数量和类型的脂肪与纤维。所有喂食脂肪的组中，每只动物的肿瘤发生率和肿瘤数量均有所增加。在饮食中添加纤维可提供部分（多不饱和脂肪）或完全（饱和脂肪）保护，以对抗脂肪的有害影响。本文讨论了脂肪与纤维之间的拮抗作用以及这些数据的临床相关性。
