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脑室内注射L-谷氨酸对绵羊体温调节的影响。

Thermoregulatory effects on the sheep of intracerebroventricular injections of L-glutamic acid.

作者信息

Bligh J, Silver A, Bacon M, Smith C A

出版信息

Experientia. 1978 Mar 15;34(3):370-1. doi: 10.1007/BF01923041.

DOI:10.1007/BF01923041
PMID:631270
Abstract

L-glutamic acid injected in doses of 200--1000 n moles . kg-1 into the cerebral ventricles of sheep had dose-dependent thermoregulatory effects: an increase in heat production and/or a decrease in respiratory frequency, and a rise in rectal temperature. A dose of 800 nmoles . kg-1 had effects comparable with those of a similar injection of 3 nmoles . kg-1 carbamylcholine.

摘要

以200 - 1000纳摩尔·千克⁻¹的剂量向绵羊脑室注射L-谷氨酸,具有剂量依赖性的体温调节作用:产热增加和/或呼吸频率降低,直肠温度升高。800纳摩尔·千克⁻¹的剂量所产生的作用与注射3纳摩尔·千克⁻¹氨甲酰胆碱的类似注射所产生的作用相当。

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引用本文的文献

1
The effects on thermoregulation of intracerebroventricular injections of L-aspartic acid in the sheep.脑室内注射L-天冬氨酸对绵羊体温调节的影响。
Experientia. 1978 Aug 15;34(8):1043-4. doi: 10.1007/BF01915336.

本文引用的文献

1
Influence of ambient temperature on the thermoregulatory responses to 5-hydroxytryptamine, noradrenaline and acetylcholine injected into the lateral cerebral ventricles of sheep, goats and rabbits.环境温度对绵羊、山羊和家兔侧脑室注射5-羟色胺、去甲肾上腺素和乙酰胆碱后体温调节反应的影响。
J Physiol. 1971 Jan;212(2):377-92. doi: 10.1113/jphysiol.1971.sp009330.
2
Sites and mechanisms of action of histamine in the central thermoregulatory pathways of the rat.组胺在大鼠中枢体温调节通路中的作用部位及作用机制。
Neuropharmacology. 1976 May;15(5):321-4. doi: 10.1016/0028-3908(76)90136-2.
3
Intracerebroventricular taurine in rabbits: effects of normal body temperature, endotoxin fever and hyperthermia produced by PGE1 and amphetamine.
兔脑室内牛磺酸:正常体温、内毒素发热以及由前列腺素E1和苯丙胺引起的体温过高的影响
J Physiol. 1977 Apr;266(2):397-410. doi: 10.1113/jphysiol.1977.sp011773.
4
A central cholinergic synapse between cold sensors and heat production effectors in the sheep: true or false [proceedings]?绵羊冷感受器与产热效应器之间的中枢胆碱能突触:是真是假[会议论文集]?
J Physiol. 1977 Mar;266(1):88P-89P.