De Roij T A, Frens J, Bakker J, Németh F
Eur J Pharmacol. 1977 May 1;43(1):1-7. doi: 10.1016/0014-2999(77)90153-4.
Dopamine (DA) was injected in the third brain ventricle of goats and the thermoregulatory effects were studied under different ambient conditions. The effects depended on dose, ambient conditions and cannula used. In the cold, there was a drop in body temperature, sometimes accompanied by suppression of shivering and by vasodilatation. Both temperature decrease and suppression of shivering were dose-dependent but there was no relation between magnitude of temperature drop and occurrence of shivering suppression. In a thermoneutral environment, there was either a slight vasoconstriction or hypothermia, occasionally accompanied by induction of panting. In the heat, either hypothermia or hyperthermia was observed. Hypothermia was accompanied by an increase in panting. Hyperthermia only occurred when the animals became excited as a result of the injection of DA. It is concluded that DA acts by stimulating the thermoregulatory pathway from heat sensors to heat loss effectors at a locus similar to that for 5-hydroxytryptamine in the thermoregulation model of Bligh et al. (1971).
将多巴胺（DA）注入山羊的第三脑室，并在不同环境条件下研究其体温调节作用。这些作用取决于剂量、环境条件和所用的套管。在寒冷环境中，体温下降，有时伴有寒颤抑制和血管舒张。体温下降和寒颤抑制均呈剂量依赖性，但体温下降幅度与寒颤抑制的发生之间没有关系。在热中性环境中，要么有轻微的血管收缩，要么有体温过低，偶尔伴有气喘的诱发。在炎热环境中，观察到体温过低或体温过高。体温过低伴有气喘增加。体温过高仅在动物因注射DA而兴奋时出现。得出的结论是，DA的作用是通过刺激从热传感器到散热效应器的体温调节途径，其作用位点类似于布莱等人（1971年）体温调节模型中5-羟色胺的作用位点。
