Chelly J, Kouyoumdjian J C, Mouillé P, Huchet A M, Schmitt H
Eur J Pharmacol. 1979 Nov 23;60(1):91-4. doi: 10.1016/0014-2999(79)90055-4.
L-Glutamic acid and kainic acid injected into the cisterna magna of dogs, produced a dose-dependent increase in blood pressure and a decrease in heart rate. In contrast, intravenous injection of both compounds was ineffective. The hypertension was probably due to an increase in sympathetic tone as guanethidine prevented the rise in blood pressure induced by central administration of L-glutamic acid and kainic acid. Kainic acid was 1 000 fold more potent than L-glutamic acid.
将L-谷氨酸和 kainic 酸注入狗的脑池，会使血压呈剂量依赖性升高，心率降低。相比之下，静脉注射这两种化合物则没有效果。这种高血压可能是由于交感神经张力增加所致，因为胍乙啶可阻止由中枢给予L-谷氨酸和 kainic 酸所引起的血压升高。kainic 酸的效力比L-谷氨酸强1000倍。
