Meiniel R
Experientia. 1978 Mar 15;34(3):394-6. doi: 10.1007/BF01923057.
Anticholinesterasic and depolarizing (analogues of acetylcholine) agents administered to quail embryos after 3 days of incubation give rise to vertebral fusions in addition to neck deformities. Antagonists of acetylcholine (gallamine and hexamethonium) produce only vertebral joint fusions. The incidence of all these compounds in the vertebral defects by the way of there neuroactive properties is proposed.
在鹌鹑胚胎孵化3天后给予抗胆碱酯酶和去极化(乙酰胆碱类似物)药物,除了导致颈部畸形外,还会引起椎体融合。乙酰胆碱拮抗剂(加拉明和六甲铵)仅产生椎间关节融合。通过这些化合物的神经活性特性,提出了它们在脊椎缺陷中的发生率。