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[在脊椎动物成体或胚胎接触有机磷酸盐后给予几种具有已知抗致畸或抗毒性特性的化合物后对硫磷轴向致畸作用。在鹌鹑胚胎(日本鹌鹑)中的研究]

[Parathion axial teratogenesis after giving several compounds with known anti-teratogenic or antitoxic properties in vertebrate adults or embryos after exposure to organic phosphates. Study in the quail embryo (Coturnix coturnix japonica)].

作者信息

Meiniel R

出版信息

C R Acad Hebd Seances Acad Sci D. 1976 Oct 18;283(9):1085-7.

PMID:826344
Abstract

Axial abnormalities, highly specific of parathion, are prevented by pyridine aldoximes P2S, 2-PAM and TMB4. Atropine, well known as an antimuscarinic agent is ineffective and so it is for tryptophan and DMSO, compounds having protective effect on some morphogenetic disturbances induced by organic phosphates. These results point out the specificity of pyridine aldoximes as alleviating agents on the characteristic axial deformities induced by parathion.

摘要

对硫磷特有的轴向异常可被吡啶肟类化合物P2S、2-解磷定和TMB4预防。阿托品作为一种熟知的抗毒蕈碱剂无效,色氨酸和二甲基亚砜对有机磷酸盐诱导的某些形态发生紊乱具有保护作用,但对硫磷也无效。这些结果指出了吡啶肟类化合物作为减轻对硫磷诱导的特征性轴向畸形的缓解剂的特异性。

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