Lindgren J E
Arch Toxicol Suppl. 1983;6:74-80. doi: 10.1007/978-3-642-69083-9_11.
The search for the psychoactive constituents of the plant Cannabis sativa L has revealed over 420 compounds to date. The synthesis of delta 1-tetrahydrocannabinol finally established the main active component of cannabis. THC is a potent drug, and plasma levels (except initially) are of the order of a few nanograms per milliliter. During the last few years, various methods based on mass spectrometry, RIA etc. have made it possible to quantitate non labelled THC and metabolites in plasma. These plasma level determinations of THC may be important for correct clinical diagnosis of cannabis intoxication, and for drug interaction studies. The various analytical techniques for cannabinoids are discussed, and updated in this paper.
对植物大麻（Cannabis sativa L）中具有精神活性成分的研究至今已发现了420多种化合物。δ1-四氢大麻酚的合成最终确定了大麻的主要活性成分。四氢大麻酚是一种强效药物，血浆水平（最初除外）约为每毫升几纳克。在过去几年中，基于质谱、放射免疫分析等的各种方法已使定量测定血浆中未标记的四氢大麻酚及其代谢物成为可能。这些四氢大麻酚血浆水平的测定对于大麻中毒的正确临床诊断以及药物相互作用研究可能很重要。本文讨论并更新了用于大麻素的各种分析技术。
