肠肽PHI对离体大鼠肝细胞糖原分解和糖异生的刺激作用。
Stimulatory effect of the intestinal peptide PHI on glycogenolysis and gluconeogenesis in isolated rat hepatocytes.
作者信息
Felíu J E, Marco J
出版信息
Biochem J. 1983 Sep 15;214(3):999-1002. doi: 10.1042/bj2140999.
Abstract
The newly isolated peptide PHI provoked a dose-dependent stimulation of glycogenolysis and gluconeogenesis in isolated rat hepatocytes; at 1 microM-PHI, both processes were increased 1.6-fold as compared with basal values. These PHI-mediated effects were accompanied by the activation of glycogen phosphorylase and the inactivation of pyruvate kinase. PHI (1 microM) also caused a 2-fold increase in hepatocyte cyclic AMP.
摘要
新分离出的肽PHI在离体大鼠肝细胞中引发了糖原分解和糖异生的剂量依赖性刺激；在1微摩尔/升的PHI浓度下，与基础值相比，这两个过程均增加了1.6倍。这些PHI介导的效应伴随着糖原磷酸化酶的激活和丙酮酸激酶的失活。1微摩尔/升的PHI还使肝细胞环磷酸腺苷增加了2倍。
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