Allan E H, Green I C, Titheradge M A
Biochem J. 1983 Nov 15;216(2):507-10. doi: 10.1042/bj2160507.
The opioid agonists [leucine]enkephalin, [D-Ala2,D-Leu5]enkephalin and dynorphin-(1-13)-peptide, but not morphine, stimulated the conversion of [2-14C]pyruvate into glucose and glycogenolysis when added directly to isolated hepatocytes. Naloxone produced a small but significant inhibition of both the basal and stimulated rate of incorporation of label into glucose but had no effect on the total glucose output by the cells. The effects of the opioid peptides were mediated by a cyclic AMP-independent mechanism.
阿片样物质激动剂[亮氨酸]脑啡肽、[D - 丙氨酸2，D - 亮氨酸5]脑啡肽和强啡肽 -（1 - 13）肽，而非吗啡，直接添加到分离的肝细胞中时，会刺激[2 - 14C]丙酮酸转化为葡萄糖以及糖原分解。纳洛酮对基础和刺激状态下标记物掺入葡萄糖的速率均产生了轻微但显著的抑制作用，但对细胞的总葡萄糖输出没有影响。阿片样肽的作用是由一种不依赖环磷酸腺苷的机制介导的。
