高钾摄入量对绵羊体内促肾上腺皮质激素（ACTH）和脱氧皮质酮（DOC）高血压作用的影响。

The influence of a high K intake on the hypertensive effect of ACTH and DOC in sheep.

作者信息

Mills E H, Coghlan J P, Denton D A, Scoggins B A, Spence C D, Whitworth J A

出版信息

Clin Exp Pharmacol Physiol. 1983 May-Jun;10(3):365-8. doi: 10.1111/j.1440-1681.1983.tb00214.x.

DOI:10.1111/j.1440-1681.1983.tb00214.x

Abstract

The effect of 5 days administration of ACTH or DOC, was examined before and after chronic potassium (K) loading in sheep. K loading raised plasma [K], urine volume and K excretion but had no effect on mean arterial pressure (MAP). On a normal K intake DOC (5 mg/day i.v.) increased MAP and plasma sodium [Na]. Plasma [K], urinary Na (day 1) and K (day 1) excretion were decreased. On a high K intake (congruent to 800 mmol K/day), DOC lowered plasma [K] but had no effect on MAP or Na excretion. The hypertensive effects of ACTH were not affected by K intake.

摘要

在绵羊慢性钾（K）负荷前后，研究了促肾上腺皮质激素（ACTH）或脱氧皮质酮（DOC）连续给药5天的效果。钾负荷增加了血浆[K]、尿量和钾排泄，但对平均动脉压（MAP）没有影响。在正常钾摄入量时，DOC（静脉注射5毫克/天）升高了MAP和血浆钠[Na]。血浆[K]、尿钠（第1天）和钾（第1天）排泄减少。在高钾摄入量（约800毫摩尔K/天）时，DOC降低了血浆[K]，但对MAP或钠排泄没有影响。ACTH的升压作用不受钾摄入量的影响。