O'Keefe E J, Pledger W J
Mol Cell Endocrinol. 1983 Aug;31(2-3):167-86. doi: 10.1016/0303-7207(83)90147-8.
PDGF is a potent mitogen that initiates the proliferation of quiescent fibroblastic cells. EGF and somatomedin C (or insulin) can replace the requirement for plasma to function synergistically with PDGF to stimulate DNA synthesis. PDGF, EGF and somatomedin C control discrete cellular events in the cell cycle. Cyclic AMP can potentiate the effects of polypeptide mitogens. The down-regulation of EGF receptors by PDGF and cyclic AMP brings about a loss of the requirement for exogenous EGF. The transient treatment of density-arrested fibroblasts with PDGF allows better study of synergistic actions of PDGF and plasma-derived factors. These synergistic interactions are important to understand in determining how multiple growth factors regulate cellular proliferation.
血小板衍生生长因子（PDGF）是一种强效的促有丝分裂原，可启动静止成纤维细胞的增殖。表皮生长因子（EGF）和生长调节素C（或胰岛素）可替代血浆需求，与PDGF协同作用以刺激DNA合成。PDGF、EGF和生长调节素C控制细胞周期中不同的细胞事件。环磷酸腺苷（cAMP）可增强多肽促有丝分裂原的作用。PDGF和cAMP对EGF受体的下调导致对外源EGF需求的丧失。用PDGF对密度抑制的成纤维细胞进行短暂处理，有助于更好地研究PDGF与血浆衍生因子的协同作用。在确定多种生长因子如何调节细胞增殖时，理解这些协同相互作用很重要。
