Tanaka R, Shima K, Kumahara Y, Matsuyama T, Tarui S, Sawazaki N
Nihon Naibunpi Gakkai Zasshi. 1978 Jan 20;54(1):23-8. doi: 10.1507/endocrine1927.54.1_23.
It has been reported that Xenopsin, Neurotensin and Substance P change plasma glucagon and insulin levels when they are administered in vivo. In order to clarify whether these agents have a direct effect on glucagon and insulin secretion from the pancreas, the action of each substance was examined by using the rat pancreas perfusion technique. The results were as follows: The perfusion with 1 and 5 nmole/min of Xenopsin for ten minutes resulted in a significant but transient release within two minutes. Neurotensin did not show any stimulatory effect on glucagon release in the concentration of 1 or 5 nmole/min for ten minutes. However, Substance P lowered significantly the glucagon concentration in the perfusate in a similar concentration. None of these substances influenced significantly insulin release from the perfused pancreas. These findings suggest that the hyperglucagonemia caused by these three agents in vivo may not be attributed to the direct effect on the pancreatic A-cell.
据报道，蛙皮素、神经降压素和P物质在体内给药时会改变血浆胰高血糖素和胰岛素水平。为了阐明这些物质是否对胰腺的胰高血糖素和胰岛素分泌有直接作用，采用大鼠胰腺灌注技术研究了每种物质的作用。结果如下：以1和5纳摩尔/分钟的速度灌注蛙皮素10分钟，在两分钟内导致显著但短暂的释放。在1或5纳摩尔/分钟的浓度下灌注10分钟，神经降压素对胰高血糖素释放没有任何刺激作用。然而，P物质在相似浓度下可显著降低灌注液中的胰高血糖素浓度。这些物质均未对灌注胰腺的胰岛素释放产生显著影响。这些发现表明，这三种物质在体内引起的高胰高血糖素血症可能并非归因于对胰腺A细胞的直接作用。
