人类促肾上腺皮质激素-β-促脂素前体基因的完整核苷酸序列。
Complete nucleotide sequence of the human corticotropin-beta-lipotropin precursor gene.
作者信息
Takahashi H, Hakamata Y, Watanabe Y, Kikuno R, Miyata T, Numa S
出版信息
Nucleic Acids Res. 1983 Oct 11;11(19):6847-58. doi: 10.1093/nar/11.19.6847.
Abstract
The nucleotide sequence of an 8658-base-pair human genomic DNA segment containing the entire corticotropin-beta-lipotropin precursor gene has been determined, and some sequence features of the gene and its flanking regions have been analysed. The gene is composed of 7665 base pairs including two introns of 3708 and 2886 base pairs. Comparison of the 5'-flanking sequences of the human, bovine and mouse corticotropin-beta-lipotropin precursor genes reveals the presence of a highly conserved region, which contains sequences of 14-15 base pairs homologous with sequences located upstream of the mRNA start site of other glucocorticoid-regulated genes.
摘要
已确定包含整个促肾上腺皮质激素-β-促脂素前体基因的一段8658个碱基对的人类基因组DNA片段的核苷酸序列，并分析了该基因及其侧翼区域的一些序列特征。该基因由7665个碱基对组成，包括两个分别为3708个和2886个碱基对的内含子。对人类、牛和小鼠促肾上腺皮质激素-β-促脂素前体基因的5'侧翼序列进行比较，发现存在一个高度保守的区域，该区域包含与其他糖皮质激素调节基因的mRNA起始位点上游序列同源的14-15个碱基对的序列。
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