Massarotti M
Pharmacol Biochem Behav. 1983;18 Suppl 1:51-4. doi: 10.1016/0091-3057(83)90146-6.
Recent research results indicate that gangliosides, complex glycolipids present in neuronal membranes, play an important functional role in nervous transmission. Physiological and pharmacological investigations have shown that the parenteral administration of a bovine cerebral cortex ganglioside preparation exerts a reinnervation-stimulating activity, due to enhanced nerve sprouting, in peripheral neuropathies. Experimental data are presented showing that the administration of ganglioside prevents the decrease of the conduction velocity, measured in the sciatic nerve of laboratory animals chronically intoxicated with ethanol. Gangliosides are also able to improve the conduction velocity in the sciatic nerve of animals already damaged by the same neurotoxic agent. With regard to therapeutical aspects in alcoholic patients with sensory or motor-sensory polyneuropathy, a review is presented covering 114 patients studied in several clinical trials by means of clinical and instrumental investigations. The clinical parameters, especially the sensory disturbances, turn out to be very responsive to ganglioside treatment. Also, the electrophysiological effects are positively influenced, even though this kind of investigation presents methodological difficulties connected with the great variability of baseline data.
最近的研究结果表明，神经节苷脂这种存在于神经元膜中的复合糖脂，在神经传递中发挥着重要的功能作用。生理学和药理学研究表明，肠胃外给予牛脑皮层神经节苷脂制剂，在周围神经病变中，由于神经芽生增强而具有促进神经再支配的活性。实验数据表明，给予神经节苷脂可防止在长期用乙醇中毒的实验动物坐骨神经中测量到的传导速度降低。神经节苷脂还能够提高已经受到相同神经毒性剂损伤的动物坐骨神经中的传导速度。关于患有感觉性或运动感觉性多神经病的酒精中毒患者的治疗方面，本文综述了在几项临床试验中通过临床和仪器检查研究的114例患者。临床参数，尤其是感觉障碍，结果显示对神经节苷脂治疗反应非常敏感。此外，电生理效应也受到积极影响，尽管这类研究存在与基线数据的巨大变异性相关的方法学困难。
