Sutherland C M, Loutfi A, Mather F J, Carter R D, Krementz E T
Surg Gynecol Obstet. 1983 Nov;157(5):443-6.
Results of this study suggest melanomas diagnosed, initiated or stimulated during pregnancy have worse prognoses than do those of patients not having this history. For those female patients who have had melanomas without a history of the preceding factors, it appears they can become pregnant following the diagnosis and treatment of melanoma without increased hazard. Further biochemical studies on hormone receptors and correlation with the clinical course are needed to clarify the influences of endocrines on malignant melanomas.
本研究结果表明,孕期诊断、始发或受刺激引发的黑色素瘤患者的预后比无此病史的患者更差。对于那些无上述因素病史的女性黑色素瘤患者,似乎在黑色素瘤诊断和治疗后可以怀孕,且风险不会增加。需要进一步开展关于激素受体的生化研究以及与临床病程的相关性研究,以阐明内分泌对恶性黑色素瘤的影响。