Klosterhalfen H, Becker H, Köllermann M W, Altenähr E
Urologe A. 1983 Sep;22 Suppl:360-6.
In a prospective study 209 patients with prostatic cancer stage C who were seen between 1968-1974 received endocrine treatment and radiotherapy (6000 r) of the prostate without inclusion of regional lymph nodes. The patients were seen every 6 months up to 8 years. 247 transrectal biopsies and 7 transurethral resections of the prostate were performed. The analysis of the biopsies revealed that the combined endocrine and radiotherapy is followed by tumor neutralisation of about 70% in highly differentiated prostatic cancers and less effective in lower differentiated tumors. 80% of biopsies from tumors responding to therapy still show tumor cells. The 5-year-survival corresponded with tumor regression and tumor size. However a prognosis on the basis of these findings is not possible for the individual case.
在一项前瞻性研究中，1968年至1974年间收治的209例C期前列腺癌患者接受了内分泌治疗和前列腺放疗（6000拉德），未包括区域淋巴结。患者每6个月复查一次，最长8年。共进行了247次经直肠活检和7次经尿道前列腺切除术。活检分析显示，在内分泌和放疗联合治疗后，高分化前列腺癌约70%的肿瘤得到中和，而低分化肿瘤的效果较差。对治疗有反应的肿瘤活检中，80%仍显示有肿瘤细胞。5年生存率与肿瘤消退和肿瘤大小相关。然而，根据这些发现无法对个体病例进行预后判断。
