结膜乳头状瘤中人乳头瘤病毒DNA序列的检测

Detection of human papillomavirus DNA sequences in conjunctival papilloma.

作者信息

Lass J H, Grove A S, Papale J J, Albert D M, Jenson A B, Lancaster W D

出版信息

Am J Ophthalmol. 1983 Nov;96(5):670-4. doi: 10.1016/s0002-9394(14)73426-9.

Abstract

Two histologically proven conjunctival papillomas (one from a 33-month-old boy and the other from a 28-year-old woman) were examined for the presence of papillomavirus by DNA molecular hybridization. The first case, a recurrent tumor known to be positive for papillomavirus structural antigen, demonstrated human papillomavirus DNA sequences that cross-hybridized to a human papillomavirus type 11 DNA probe. The second case, an initial tumor, which was negative for papillomavirus structural antigen, demonstrated no viral DNA sequences by hybridization.

摘要

通过DNA分子杂交技术，对两例经组织学证实的结膜乳头状瘤（一例来自一名33个月大的男孩，另一例来自一名28岁的女性）进行乳头瘤病毒检测。第一例为复发性肿瘤，已知乳头瘤病毒结构抗原呈阳性，检测显示人乳头瘤病毒DNA序列与11型人乳头瘤病毒DNA探针发生交叉杂交。第二例为原发性肿瘤，乳头瘤病毒结构抗原呈阴性，杂交检测未显示病毒DNA序列。