Naqi S A, Marquez B, Sahin N
Avian Dis. 1983 Jul-Sep;27(3):623-31.
Chickens vaccinated with infectious bursal disease virus (IBDV) early in life and revaccinated with an inactivated, oil-adjuvant IBDV vaccine at 18 weeks of age produced and maintained high levels of virus-neutralizing (VN) antibody through 10 months of lay. VN-antibody titers of chicks hatched from eggs laid during the same period closely matched the average VN-antibody titers of the dams. A sequential study of the decline rates of IBDV maternal antibody (MAB) in unvaccinated and IBDV-vaccinated chicks showed that the vaccine virus did not accelerate the antibody depletion rate in vaccinated chicks. Chicks carrying high IBDV MAB showed no active immune response to vaccination with commercial IBDV vaccines. They were also refractory to a pathogenic field isolate of IBDV (FV). However, chicks with low levels of MAB responded to both vaccine virus and the FV, although their response to vaccine virus was milder and delayed.
在幼雏阶段早期用传染性法氏囊病病毒（IBDV）进行免疫接种，并在18周龄时用灭活的油佐剂IBDV疫苗进行再次免疫接种的母鸡，在整个10个月的产蛋期内产生并维持了高水平的病毒中和（VN）抗体。同期所产蛋孵化出的雏鸡的VN抗体滴度与母鸡的平均VN抗体滴度密切匹配。一项对未接种疫苗和接种IBDV疫苗的雏鸡中IBDV母源抗体（MAB）下降速率的序贯研究表明，疫苗病毒并未加速接种疫苗雏鸡的抗体消耗速率。携带高IBDV MAB的雏鸡对商用IBDV疫苗接种无主动免疫反应。它们对IBDV的致病野毒株（FV）也具有抗性。然而，MAB水平较低的雏鸡对疫苗病毒和FV均有反应，尽管它们对疫苗病毒的反应较温和且延迟。
