蜘蛛毒素（JSTX）对鱿鱼巨大突触中突触传递的阻断作用。

Blockade of synaptic transmission in the squid giant synapse by a spider toxin (JSTX).

作者信息

Kawai N, Yamagishi S, Saito M, Furuya K

出版信息

Brain Res. 1983 Nov 14;278(1-2):346-9. doi: 10.1016/0006-8993(83)90269-x.

Abstract

We studied the effect of spider toxin (JSTX)--specific blocker of glutamate receptor--on giant synapse of the squid stellate ganglion. JSTX irreversibly blocked the excitatory postsynaptic potential (EPSP) without affecting the presynaptic action potential or the antidromic action potential. L-glutamate depolarized the postsynaptic membrane and suppressed EPSP which may be due to desensitization. The action of glutamate was completely blocked in the presence of JSTX. The results suggest that glutamate is the transmitter at the giant synapse of squid.

摘要

我们研究了蜘蛛毒素（JSTX）——谷氨酸受体的特异性阻断剂——对鱿鱼星状神经节巨大突触的作用。JSTX不可逆地阻断兴奋性突触后电位（EPSP），而不影响突触前动作电位或逆向动作电位。L-谷氨酸使突触后膜去极化并抑制EPSP，这可能是由于脱敏作用。在JSTX存在的情况下，谷氨酸的作用被完全阻断。结果表明，谷氨酸是鱿鱼巨大突触处的神经递质。