抗氧化剂对苯并[a]芘体外代谢及致突变性的影响。
The effects of antioxidants on the metabolism and mutagenicity of benzo[a]pyrene in vitro.
作者信息
Rahimtula A D, Zachariah P K, O'Brien P J
出版信息
Biochem J. 1977 May 15;164(2):473-5. doi: 10.1042/bj1640473.
Abstract
Antioxidants inhibit the rat liver microsomal mixed-function-oxidase-catalysed hydroxylation of benzo[a]pyrene. These antioxidants also decrease the formation of mutagenic products from benzo[a]pyrene as judged by the Ames bacterial-mutagenicity assay [B.N. Ames, J. McCann & E. Yamazaki (1975) Mutat. Res. 31, 347-364]. It is suggested that antioxidants exert their protective effect against cancer by inhibiting the formation of carcinogenic metabolites.
摘要
抗氧化剂可抑制大鼠肝脏微粒体混合功能氧化酶催化的苯并[a]芘羟基化反应。通过艾姆斯细菌诱变性试验[B.N.艾姆斯、J.麦肯和E.山崎（1975年），《突变研究》31卷，第347 - 364页]判断，这些抗氧化剂还能减少苯并[a]芘诱变产物的形成。有人提出，抗氧化剂通过抑制致癌代谢物的形成发挥其抗癌保护作用。
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