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抗氧化剂对苯并[a]芘体外代谢及致突变性的影响。

The effects of antioxidants on the metabolism and mutagenicity of benzo[a]pyrene in vitro.

作者信息

Rahimtula A D, Zachariah P K, O'Brien P J

出版信息

Biochem J. 1977 May 15;164(2):473-5. doi: 10.1042/bj1640473.

DOI:10.1042/bj1640473
PMID:328015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1164816/
Abstract

Antioxidants inhibit the rat liver microsomal mixed-function-oxidase-catalysed hydroxylation of benzo[a]pyrene. These antioxidants also decrease the formation of mutagenic products from benzo[a]pyrene as judged by the Ames bacterial-mutagenicity assay [B.N. Ames, J. McCann & E. Yamazaki (1975) Mutat. Res. 31, 347-364]. It is suggested that antioxidants exert their protective effect against cancer by inhibiting the formation of carcinogenic metabolites.

摘要

抗氧化剂可抑制大鼠肝脏微粒体混合功能氧化酶催化的苯并[a]芘羟基化反应。通过艾姆斯细菌诱变性试验[B.N.艾姆斯、J.麦肯和E.山崎（1975年），《突变研究》31卷，第347 - 364页]判断，这些抗氧化剂还能减少苯并[a]芘诱变产物的形成。有人提出，抗氧化剂通过抑制致癌代谢物的形成发挥其抗癌保护作用。

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本文引用的文献

1
Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by phenolic antioxidants and ethoxyquin.酚类抗氧化剂和乙氧喹对多环烃致癌和毒性作用的抑制
J Natl Cancer Inst. 1972 May;48(5):1425-30.
2
Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by several sulfur-containing compounds.几种含硫化合物对多环烃致癌和毒性作用的抑制
J Natl Cancer Inst. 1974 May;52(5):1583-7. doi: 10.1093/jnci/52.5.1583.
3
Inhibition of chemical carcinogen-induced pulmonary neoplasia by butylated hydroxyanisole.丁基羟基茴香醚对化学致癌物诱导的肺肿瘤形成的抑制作用。
J Natl Cancer Inst. 1973 Jun;50(6):1541-4. doi: 10.1093/jnci/50.6.1541.
4
Effect of the antioxidant butylated hydroxytoluene (BHT) on the metabolism of the carcinogens N-2-fluorenylacetamide and N-hydroxy-N-2-fluorenylacetamide.抗氧化剂丁基羟基甲苯（BHT）对致癌物N-2-芴基乙酰胺和N-羟基-N-2-芴基乙酰胺代谢的影响。
Food Cosmet Toxicol. 1973 Apr;11(2):209-17. doi: 10.1016/s0015-6264(73)80487-0.
5
Inhibition of the mono-oxygenase system by butylated hydroxyanisole and butylated hydroxytoluene.丁基羟基茴香醚和丁基羟基甲苯对单加氧酶系统的抑制作用。
Life Sci. 1974 Oct 15;15(8):1497-505. doi: 10.1016/0024-3205(74)90124-6.
6
Inhibition of NADPH-cytochrome c reductase by propyl gallate.棓丙酯对NADPH-细胞色素c还原酶的抑制作用。
Biochem Pharmacol. 1971 Aug;20(8):2027-32. doi: 10.1016/0006-2952(71)90402-3.
7
Role of hemoprotein P-450 in fatty acid omega-hydroxylation in a soluble enzyme system from liver microsomes.血红素蛋白P-450在肝脏微粒体可溶性酶系统中脂肪酸ω-羟化反应中的作用。
J Biol Chem. 1968 Mar 25;243(6):1331-2.
8
Pharmacological implications of microsomal enzyme induction.微粒体酶诱导的药理学意义。
Pharmacol Rev. 1967 Sep;19(3):317-66.
9
Modification of the acute toxicity of mutagenic and carcinogenic chemicals in the mouse by prefeeding with antioxidants.通过预先喂食抗氧化剂来改变诱变和致癌化学物质对小鼠的急性毒性。
Food Cosmet Toxicol. 1973 Aug;11(4):547-53. doi: 10.1016/s0015-6264(73)80325-6.
10
Antioxidants and carcinogenesis: butylated hydroxytoluene, but not diphenyl-p-phenylenediamine, inhibits cancer induction by N-2-fluorenylacetamide and by N-hydroxy-N-2-fluorenylacetamide in rats.抗氧化剂与致癌作用：丁基羟基甲苯可抑制大鼠体内由N-2-芴基乙酰胺和N-羟基-N-2-芴基乙酰胺诱导的癌症发生，而二苯胺对苯二胺则无此作用。
Food Cosmet Toxicol. 1973 Apr;11(2):199-207. doi: 10.1016/s0015-6264(73)80486-9.