石棉激活的巨噬细胞与实验性纤维肉瘤的相互作用。
Interactions of asbestos-activated macrophages with an experimental fibrosarcoma.
作者信息
Donaldson K, Davis J M, Ewing A, James K
出版信息
Environ Health Perspect. 1983 Sep;51:97-101. doi: 10.1289/ehp.835197.
Abstract
Supernatants from in vivo asbestos-activated macrophages failed to show any cytostatic activity against a syngeneic fibrosarcoma cell line in vitro. UICC chrysotile-induced peritoneal exudate cells also failed to demonstrate any growth inhibitory effect on the same cells in Winn assays of tumor growth. Mixing UICC crocidolite with inoculated tumor cells resulted in a dose-dependent inhibition of tumor growth; this could, however, be explained by a direct cytostatic effect on the tumor cells of high doses of crocidolite, which was observed in vitro.
摘要
体内石棉激活的巨噬细胞的上清液在体外对同基因纤维肉瘤细胞系未显示出任何细胞抑制活性。国际抗癌联盟（UICC）温石棉诱导的腹腔渗出细胞在肿瘤生长的温氏试验中对相同细胞也未表现出任何生长抑制作用。将UICC青石棉与接种的肿瘤细胞混合导致肿瘤生长呈剂量依赖性抑制；然而，这可以用高剂量青石棉对肿瘤细胞的直接细胞抑制作用来解释，这种作用在体外已观察到。
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