秀丽隐杆线虫中的交叉抑制因子和平衡隐性致死基因
Crossover suppressors and balanced recessive lethals in Caenorhabditis elegans.
作者信息
Herman R K
出版信息
Genetics. 1978 Jan;88(1):49-65. doi: 10.1093/genetics/88.1.49.
Abstract
Two dominant suppressors of crossing over have been identified following X-ray treatment of the small nematode C. elegans. They suppress crossing over in linkage group II (LGII) about 100-fold and 50-fold and are both tightly linked to LGII markers. One, called C1, segregates independently of all other linkage groups and is homozygous fertile. The other is a translocation involving LGII and X. The translocation also suppresses crossing over along the right half of X and is homozygous lethal. C1 has been used as a balancer of LGII recessive lethal and sterile mutations induced by EMS. The frequencies of occurrence of lethals and steriles were approximately equal. Fourteen mutations were assigned to complementation groups and mapped. They tended to map in the same region where LGII visibles are clustered.
摘要
在用X射线处理小型线虫秀丽隐杆线虫后，已鉴定出两种主要的交叉抑制因子。它们使连锁群II（LGII）中的交叉抑制约100倍和50倍，并且都与LGII标记紧密连锁。一种称为C1，与所有其他连锁群独立分离，且纯合可育。另一种是涉及LGII和X的易位。该易位还抑制了X染色体右半部分的交叉，并且纯合致死。C1已被用作平衡由EMS诱导的LGII隐性致死和不育突变的平衡子。致死和不育的发生频率大致相等。14个突变被分配到互补群并进行了定位。它们倾向于定位在LGII可见基因聚集的同一区域。
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