Lowell D M, LiVolsi V A, Ludwig M E
Int J Gynecol Pathol. 1983;2(3):294-302. doi: 10.1097/00004347-198303000-00007.
Six women who underwent radiation therapy for gynecologic malignancies demonstrated cytologic evidence of condyloma virus infection 2 or more years following radiation. Histologic confirmation was obtained in two of the cases. A seventh patient developed in situ and invasive squamous cell carcinoma in a vulvar condyloma acuminatum following radiation therapy for Hodgkin's disease. This venereal infection is found most frequently in sexually active younger women (average age, 27 years). It is felt that depressed cell-mediated immunity consequent to the radiation therapy allowed the development of this infection in the older patients described in this report. The evolution of invasive squamous cell carcinoma in the condyloma acuminatum may indicate a possible oncogenic or cocarcinogenic effect of the virus. The immunologic responses to infection caused by the human papillomavirus group are discussed, as well as its potential for malignant transformation.
六名接受妇科恶性肿瘤放射治疗的女性在放疗后两年或更长时间出现了细胞学证据表明的尖锐湿疣病毒感染。其中两例获得了组织学证实。第七例患者在接受霍奇金病放射治疗后，在外阴尖锐湿疣中发生了原位和浸润性鳞状细胞癌。这种性传播感染最常见于性活跃的年轻女性（平均年龄27岁）。据认为，放疗导致的细胞介导免疫抑制使得本报告中描述的老年患者发生了这种感染。尖锐湿疣中浸润性鳞状细胞癌的演变可能表明该病毒具有潜在的致癌或协同致癌作用。本文讨论了人乳头瘤病毒组引起的感染的免疫反应及其恶性转化的可能性。
