Skolnick P, Paul S M
J Clin Psychiatry. 1983 Nov;44(11 Pt 2):12-20.
Advances in understanding the neurobiologic bases of anxiety are reviewed. The discovery of a class of compounds generically known as "benzodiazepine antagonists" has been central to much of this work. One such group of compounds, the beta-carbolines, cause convulsions, produce an anxiety-like syndrome in primates, and reduce sleep. These compounds will provide a valuable means of investigating the mechanism of action of potential anxiolytics and of drugs currently used to treat anxious patients.
本文综述了在理解焦虑症神经生物学基础方面的进展。一类通常被称为“苯二氮䓬拮抗剂”的化合物的发现是这项工作的核心。其中一组这样的化合物，即β-咔啉，会引发惊厥，在灵长类动物中产生类似焦虑的综合征，并减少睡眠。这些化合物将为研究潜在抗焦虑药物以及目前用于治疗焦虑症患者的药物的作用机制提供有价值的手段。
