Hama S, Kurimura T
J Infect. 1983 Sep;7(2):125-9. doi: 10.1016/s0163-4453(83)90506-6.
Sera from 110 healthy pregnant women in the third trimester and from 47 controls matched for age, sex and socio-economic status were tested for the presence of antibodies to three antigenic preparations believed to contain mainly alpha, beta, and gamma polypeptides of herpes simplex virus (HSV) type I. Sixty-five of the 110 pregnant women and 22 of the 47 controls possessed antibodies against HSV immediate early antigen, or alpha polypeptides. Among them, three women possessed antibodies against immediate early antigen only. The pregnant group had significantly more women with antibody against all of the three antigenic preparations (60/110) than did the control group (18/47). We conclude that in some women only early genetically determined viral products were produced and that the pregnant state affected the genetic expression of latently infecting HSV.
对110名妊娠晚期健康孕妇以及47名年龄、性别和社会经济地位相匹配的对照者的血清进行检测，以确定其是否存在针对三种抗原制剂的抗体，这三种抗原制剂据信主要包含I型单纯疱疹病毒（HSV）的α、β和γ多肽。110名孕妇中有65名以及47名对照者中有22名拥有针对HSV立即早期抗原或α多肽的抗体。其中，三名女性仅拥有针对立即早期抗原的抗体。孕妇组中拥有针对所有三种抗原制剂抗体的女性（60/110）明显多于对照组（18/47）。我们得出结论，在一些女性中仅产生了早期由基因决定的病毒产物，并且妊娠状态影响了潜伏感染的HSV的基因表达。
