Panganiban A T, Temin H M
Nature. 1983;306(5939):155-60. doi: 10.1038/306155a0.
Deletion of specific nucleotides at either end of the long terminal repeat of the avian retrovirus, spleen necrosis virus, results in replication-competent but integration-defective virus. This result supports two conclusions: (1) the 5-base pair terminal inverted repeats and three to seven adjacent nucleotides are required for integration; (2) integration of retrovirus DNA is not required for retrovirus gene expression.
禽类逆转录病毒——脾坏死病毒长末端重复序列两端特定核苷酸的缺失，会产生具有复制能力但整合缺陷的病毒。这一结果支持了两个结论：（1）整合需要5个碱基对的末端反向重复序列以及三到七个相邻核苷酸；（2）逆转录病毒基因表达不需要逆转录病毒DNA的整合。
