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一种禽逆转录病毒长末端重复序列U3区域的自发变异与合成

Spontaneous variation and synthesis in the U3 region of the long terminal repeat of an avian retrovirus.

作者信息

Shimotohno K, Temin H M

出版信息

J Virol. 1982 Jan;41(1):163-71. doi: 10.1128/JVI.41.1.163-171.1982.

DOI:10.1128/JVI.41.1.163-171.1982
PMID:6283110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC256737/
Abstract

Recombinant DNA clones of a viral clone of spleen necrosis virus, an avian retrovirus, were found to have long terminal repeats of different sizes. The variation was in the U3 region of the long terminal repeats, and any one clone had U3 of the same size in both long terminal repeats. The U3 regions in the 5' and 3' long terminal repeat were shown both to be derived from the 3' long terminal repeat of parental virus DNA.

摘要

脾脏坏死病毒（一种禽逆转录病毒）的病毒克隆的重组DNA克隆被发现具有不同大小的长末端重复序列。这种变异存在于长末端重复序列的U3区域，并且任何一个克隆在两个长末端重复序列中都具有相同大小的U3。5'和3'长末端重复序列中的U3区域均显示源自亲本病毒DNA的3'长末端重复序列。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5741/256737/064548d77e7f/jvirol00160-0185-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5741/256737/332ac9ccfa71/jvirol00160-0180-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5741/256737/1a41c483008c/jvirol00160-0181-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5741/256737/db060b685f1a/jvirol00160-0182-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5741/256737/2d3e3951de96/jvirol00160-0183-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5741/256737/064548d77e7f/jvirol00160-0185-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5741/256737/332ac9ccfa71/jvirol00160-0180-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5741/256737/1a41c483008c/jvirol00160-0181-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5741/256737/db060b685f1a/jvirol00160-0182-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5741/256737/2d3e3951de96/jvirol00160-0183-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5741/256737/064548d77e7f/jvirol00160-0185-a.jpg

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本文引用的文献

1
The structure and evolution of the human beta-globin gene family.人类β-珠蛋白基因家族的结构与进化
Cell. 1980 Oct;21(3):653-68. doi: 10.1016/0092-8674(80)90429-8.
2
Mapping of alterations in noninfectious proviruses of spleen necrosis virus.脾坏死病毒非感染性前病毒改变的图谱分析
J Virol. 1981 Jul;39(1):138-49. doi: 10.1128/JVI.39.1.138-149.1981.
3
No apparent nucleotide sequence specificity in cellular DNA juxtaposed to retrovirus proviruses.与逆转录病毒前病毒并列的细胞DNA中无明显的核苷酸序列特异性。
人类免疫缺陷病毒1型感染细胞及部分重构无细胞系统中的不连续正链DNA合成
J Virol. 1997 Dec;71(12):9259-69. doi: 10.1128/JVI.71.12.9259-9269.1997.
4
Long terminal repeat enhancer core sequences in proviruses adjacent to c-myc in T-cell lymphomas induced by a murine retrovirus.在由鼠逆转录病毒诱导的T细胞淋巴瘤中，与c-myc相邻的前病毒中的长末端重复增强子核心序列。
J Virol. 1995 Jan;69(1):446-55. doi: 10.1128/JVI.69.1.446-455.1995.
5
High rate of genetic rearrangement during replication of a Moloney murine leukemia virus-based vector.基于莫洛尼鼠白血病病毒的载体在复制过程中基因重排率高。
J Virol. 1993 Nov;67(11):6357-64. doi: 10.1128/JVI.67.11.6357-6364.1993.
6
Spontaneous changes in nucleotide sequence in proviruses of spleen necrosis virus, an avian retrovirus.脾脏坏死病毒（一种禽逆转录病毒）原病毒核苷酸序列的自发变化。
Proc Natl Acad Sci U S A. 1982 Feb;79(4):1230-4. doi: 10.1073/pnas.79.4.1230.
7
A fps gene without gag gene sequences transforms cells in culture and induces tumors in chickens.一个不含gag基因序列的fps基因可在培养中转化细胞并在鸡体内诱发肿瘤。
J Virol. 1983 Dec;48(3):744-51. doi: 10.1128/JVI.48.3.744-751.1983.
8
Complete nucleotide sequence of an infectious clone of Friend spleen focus-forming provirus: gp55 is an envelope fusion glycoprotein.弗氏脾脏集落形成前病毒感染性克隆的完整核苷酸序列：gp55是一种包膜融合糖蛋白。
Proc Natl Acad Sci U S A. 1983 Aug;80(16):5037-41. doi: 10.1073/pnas.80.16.5037.
9
Nucleotide sequences of the retroviral long terminal repeats and their adjacent regions.逆转录病毒长末端重复序列及其相邻区域的核苷酸序列。
Nucleic Acids Res. 1984 Feb 24;12(4):1767-78. doi: 10.1093/nar/12.4.1767.
10
Expression of Ty-lacZ fusions in Saccharomyces cerevisiae.Ty-lacZ融合蛋白在酿酒酵母中的表达。
Nucleic Acids Res. 1984 Feb 10;12(3):1627-40. doi: 10.1093/nar/12.3.1627.
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4
In vivo sequence requirements of the SV40 early promotor region.猴空泡病毒40早期启动子区域的体内序列要求
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5
Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus.劳氏肉瘤病毒长末端重复序列中功能性启动子的鉴定
Cell. 1980 Dec;22(3):787-97. doi: 10.1016/0092-8674(80)90555-3.
6
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Cell. 1980 Nov;22(2 Pt 2):379-86. doi: 10.1016/0092-8674(80)90348-7.
7
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Proc Natl Acad Sci U S A. 1980 Sep;77(9):5234-8. doi: 10.1073/pnas.77.9.5234.
8
Nucleotide sequences of integrated Moloney sarcoma provirus long terminal repeats and their host and viral junctions.整合的莫洛尼肉瘤前病毒长末端重复序列及其宿主与病毒连接区的核苷酸序列。
Proc Natl Acad Sci U S A. 1980 Jul;77(7):3937-41. doi: 10.1073/pnas.77.7.3937.
9
Synthesis and integration of avian sarcoma virus DNA.禽肉瘤病毒DNA的合成与整合
Cold Spring Harb Symp Quant Biol. 1980;44 Pt 2,:1091-6. doi: 10.1101/sqb.1980.044.01.117.
10
Structure of Moloney murine leukemia viral DNA: nucleotide sequence of the 5' long terminal repeat and adjacent cellular sequences.莫洛尼鼠白血病病毒DNA的结构：5' 长末端重复序列及相邻细胞序列的核苷酸序列
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3307-11. doi: 10.1073/pnas.77.6.3307.