Busse O, Aigner K, Wilimzig H
Recent Results Cancer Res. 1983;86:264-7. doi: 10.1007/978-3-642-82025-0_44.
Of 16 patients treated, all who could be examined after isolated hyperthermic lower limb perfusion with cis-platinum showed peripheral nerve damage, particularly of the lower leg and foot. We found a close correlation between the severity of neurological deficit and the perfusion temperature. The dose of cytostatic agent also plays a role in development of the nerve lesion. The major cause of the nerve damage seems to be the neurotoxicity of cis-platinum. The edematous swelling in the compartments in the lower leg have an influence. The reversibility of the pareses was generally very small.
在接受治疗的16例患者中，所有在顺铂隔离热下肢灌注后能够接受检查的患者均出现周围神经损伤，尤其是小腿和足部。我们发现神经功能缺损的严重程度与灌注温度之间存在密切相关性。细胞毒性药物的剂量在神经病变的发展中也起作用。神经损伤的主要原因似乎是顺铂的神经毒性。小腿各腔室的水肿肿胀也有影响。麻痹的可逆性通常非常小。
