Maron M B, Crowe T D, Braughler J M
Respiration. 1984;45(1):39-44. doi: 10.1159/000194595.
The injection of a single bolus of the gas phase of cigarette smoke into the airway of an isolated, perfused and ventilated, canine lung preparation resulted in a sevenfold increase in lung cyclic GMP content by 2 s after exposure. Recovery of control levels occurred by 2 min after injection. Repeated smoke exposures of the same lung resulted in similar increases. These results indicate that cigarette smoke may activate lung guanylate cyclase when delivered through the airway and suggest that lung cyclic GMP levels may fluctuate acutely during smoking.
将单剂量香烟烟雾气相注入离体、灌注和通气的犬肺标本气道后，暴露2秒时肺组织中环磷酸鸟苷（cGMP）含量增加了7倍。注射后2分钟恢复到对照水平。对同一肺组织反复进行烟雾暴露会产生类似的增加。这些结果表明，当通过气道输送时，香烟烟雾可能激活肺组织中的鸟苷酸环化酶，并提示吸烟过程中肺组织cGMP水平可能会急剧波动。
