Coulon G, Fellmann D, Arbez-Gindre F, Pageaut G
Sem Hop. 1983 Nov 3;59(40):2747-50.
The incidence of latent pituitary microadenoma is poorly known as few studies have as yet been carried out. To address this problem, microadenoma was systematically looked for during 100 random routine post-mortem examinations in subjects with no endocrine disorders. Microadenoma was found in ten cases. Immunocytochemical study demonstrated prolactinoma in 6 cases, somatotropic adenoma in 1, mixed adenoma in 1, and non-functional adenoma in 2. Microadenoma seems more prevalent between fifty and sixty years of age. Outcome is discussed: spontaneous resolution, growth with onset of clinical manifestations, or persistence without changes in size.
由于目前开展的研究较少，隐匿性垂体微腺瘤的发病率鲜为人知。为解决这一问题，我们在100例无内分泌疾病的随机常规尸检中系统地查找微腺瘤。发现10例存在微腺瘤。免疫细胞化学研究显示，其中6例为催乳素瘤，1例为生长激素腺瘤，1例为混合性腺瘤，2例为无功能腺瘤。微腺瘤似乎在50至60岁之间更为常见。文中还讨论了其转归情况：自发消退、随着临床表现出现而生长或大小不变持续存在。
