Spanier J G, Cleary P P
Virology. 1983 Oct 30;130(2):514-22. doi: 10.1016/0042-6822(83)90104-6.
When the group A streptococcal bacteriophage SP24 was propagated on an unrelated host strain CS112, it underwent a DNA rearrangement: the rearrangement involved a substitution of unique DNA (2.5 kb) from an unrelated endogenous prophage carried by strain CS112. This substitution event occurred reproducibly upon infection of strain CS112, as DNAs from a number of independent isolates were found to contain similar, but not identical, DNA sequences. Restriction endonuclease mapping suggested that recombination between homologous sequences shared by the infecting phage and the prophage produced the rearrangement. The recombinant phage was shown to adsorb more rapidly to CS112 cells than did wild type SP24 phage particles: It therefore has a selective advantage during multiple rounds of infection.
当A组链球菌噬菌体SP24在不相关的宿主菌株CS112上繁殖时，它经历了DNA重排：这种重排涉及到用CS112菌株携带的不相关内源性原噬菌体中的独特DNA（2.5 kb）进行替换。当感染CS112菌株时，这种替换事件可重复性地发生，因为从许多独立分离株中获得的DNA被发现含有相似但不相同的DNA序列。限制性内切酶图谱分析表明，感染性噬菌体和原噬菌体共有的同源序列之间的重组产生了这种重排。结果显示，重组噬菌体比野生型SP24噬菌体颗粒更快地吸附到CS112细胞上：因此，在多轮感染过程中它具有选择性优势。
