二乙基二硫代氨基甲酸钠（氨荒甲钠）与癌症

Sodium diethyldithiocarbamate (imuthiol) and cancer.

作者信息

Renoux G, Renoux M, Lemarie E, Lavandier M, Greco J, Bardos P, Lang J M, Boilleto A, Oberling F, Armand J

出版信息

Adv Exp Med Biol. 1983;166:223-39. doi: 10.1007/978-1-4757-1410-4_19.

Abstract

Sodium diethyldithiocarbamate (imuthiol), a nonantigenic, nontoxic and noncarcinogenic compound, evinces distinctive properties in recruitment and activation of T cells, and no direct influences on B cells or macrophages. The biological attributes of imuthiol (destruction of neoplastic cells, bacteria, fungi and parasites; a detoxifying influence against carcinogens or agents toxic for the liver) could strengthen its activity as a biological response modifier. Preliminary clinic testings show that imuthiol restores T cell activities and regulates the ratio among T cell subsets in cancer patients, without untoward side effects.

摘要

二乙基二硫代氨基甲酸钠（氨硫脲）是一种无抗原性、无毒且无致癌性的化合物，在T细胞的募集和激活方面表现出独特的特性，对B细胞或巨噬细胞无直接影响。氨硫脲的生物学特性（破坏肿瘤细胞、细菌、真菌和寄生虫；对致癌物或对肝脏有毒的物质具有解毒作用）可以增强其作为生物反应调节剂的活性。初步临床试验表明，氨硫脲可恢复癌症患者的T细胞活性并调节T细胞亚群之间的比例，且无不良副作用。