Stokes G S
Anaesth Intensive Care. 1983 Nov;11(4):369-76. doi: 10.1177/0310057X8301100409.
The renin-angiotensin system is one of a number of interlinked mechanisms regulating vascular resistance and blood volume. Under certain conditions it may become a predominant factor in maintaining vascular tone. Knowledge about these conditions (sodium depletion, mineralocorticoid deficiency, renovascular hypertension and iatrogenic hyperreninaemic states) is important for the safe and effective use of drugs which inhibit the renin-angiotensin system. Measurements of plasma renin activity are useful in the diagnostic assessment of hypertensive patients with hypokalaemia or evidence of renal artery stenosis. They may also have a place in the management of refractory or dialysis-resistant hypertension. Their use in the selection of antihypertensive therapy for the individual patient is controversial. Sequential measurements of plasma renin are helpful in analysing states of electrolyte depletion, and in titrating therapy for Addison's disease.
肾素-血管紧张素系统是调节血管阻力和血容量的多种相互关联机制之一。在某些情况下，它可能成为维持血管张力的主要因素。了解这些情况（钠缺乏、盐皮质激素缺乏、肾血管性高血压和医源性高肾素血症状态）对于安全有效地使用抑制肾素-血管紧张素系统的药物很重要。血浆肾素活性的测定对于低钾血症或有肾动脉狭窄证据的高血压患者的诊断评估很有用。它们在难治性或透析抵抗性高血压的管理中也可能有一席之地。它们在为个体患者选择抗高血压治疗中的应用存在争议。血浆肾素的连续测量有助于分析电解质缺乏状态，并用于调整艾迪生病的治疗。
