Danser A H, Saris J J, Schuijt M P, van Kats J P
Department of Pharmacology, Erasmus University Rotterdam, The Netherlands.
Cardiovasc Res. 1999 Nov;44(2):252-65. doi: 10.1016/s0008-6363(99)00202-3.
The existence of a local renin-angiotensin system in the heart is still a controversial issue. This review discusses the evidence, obtained from studies in cardiac cells, in isolated perfused hearts and in intact animals and humans, both under normal and pathological conditions, for local production of prorenin, renin, angiotensinogen, angiotensin-converting enzyme, angiotensin I and angiotensin II at cardiac tissue sites. In addition, the role of alternative angiotensin-generating enzymes (cathepsin, chymase) and the possibility of (pro)renin uptake from the circulation is evaluated.
心脏中局部肾素-血管紧张素系统的存在仍然是一个有争议的问题。本综述讨论了在正常和病理条件下，从心脏细胞、离体灌注心脏以及完整动物和人体研究中获得的证据，这些证据涉及心脏组织部位局部产生的肾素原、肾素、血管紧张素原、血管紧张素转换酶、血管紧张素I和血管紧张素II。此外，还评估了替代血管紧张素生成酶（组织蛋白酶、糜酶）的作用以及从循环中摄取（前）肾素的可能性。
