Oleĭnik A N, Ovsiannikova L M
Antibiotiki. 1983 Nov;28(11):845-8.
It was shown on male rats that like ethanol tetracycline increased lipid peroxidation (LPO) in the hepatocyte membranes, evident from increased levels of diene conjugates and malone dialdehyde in the liver homogenates, especially on their combination. The signal amplitude of the EPR-forms of cytochrome P-450 and Cu-, Mo- and Fe-containing proteins did not change, while the content of the EPR-forms of the free radicals increased. High efficiency of antioxidants, such as tocopherol acetate, sodium selenite and tincture of Astragalus L. is indirect evidence of the role of the free radicals in initiation of LPO in tetracycline affections of the liver.
在雄性大鼠身上的研究表明，与乙醇类似，四环素会增加肝细胞膜中的脂质过氧化（LPO），这从肝脏匀浆中二烯共轭物和丙二醛水平的升高可以明显看出，尤其是在它们联合使用时。细胞色素P - 450以及含铜、钼和铁的蛋白质的电子顺磁共振（EPR）形式的信号幅度没有变化，而自由基的EPR形式的含量增加。抗氧化剂如醋酸生育酚、亚硒酸钠和黄芪酊的高效性间接证明了自由基在四环素引起的肝脏病变中引发LPO的作用。
