Skakun N P, Vysotskiĭ I Iu
Antibiotiki. 1982;27(9):684-7.
The experiments with albino rats showed that tetracyclines used in high doses (up to 0.5 g/kg bw) increased peroxidation of lipid unsaturated fatty acids of the liver cell membranes. This was evident from the increased content of malonic dialdehyde and diene conjugates in the homogenates of the liver and blood. The prooxidant effect was most characteristic of chlortetracycline and, to a less measure, of tetracycline and oxytetracycline. It is suggested that increased lipid peroxidation plays a definite role in the pathogenesis of the liver tetracycline affections.
对白化大鼠进行的实验表明，高剂量（高达0.5克/千克体重）使用四环素会增加肝细胞膜脂质不饱和脂肪酸的过氧化作用。这从肝脏和血液匀浆中丙二醛和二烯共轭物含量的增加可以明显看出。促氧化作用在金霉素中最为显著，其次是四环素和土霉素。有人认为，脂质过氧化增加在四环素所致肝脏病变的发病机制中起一定作用。
