鼠冠状病毒的抗原关系。
Antigenic relationships of murine coronaviruses.
作者信息
Childs J C, Stohlman S A, Kingsford L, Russell R
出版信息
Arch Virol. 1983;78(1-2):81-8. doi: 10.1007/BF01310860.
Two serological tests were used to examine the antigenic relationships between murine hepatitis viruses that cause different diseases in mice. Antisera prepared by immunization of mice with the individual viruses were tested for their ability to neutralize both the homologous immunogen and the other viruses. By a plaque reduction neutralization test, each antiserum was found to be specific for the immunizing virus; however, there was substantial cross-reactivity, indicating the viruses were closely related. By kinetic neutralization, two of the viruses tested, MHV-JHM and MHV-2, were found to be antigenically distinct. MHV-3 and MHV-A59 were found to be antigenically very similar but distinct. These data show that kinetic neutralization is a more precise method for determining the antigenic relationships between murine coronaviruses.
使用两种血清学检测方法来研究在小鼠中引发不同疾病的鼠肝炎病毒之间的抗原关系。用单个病毒免疫小鼠制备的抗血清，检测其中和同源免疫原及其他病毒的能力。通过蚀斑减少中和试验发现，每种抗血清对免疫病毒具有特异性；然而，存在大量交叉反应，表明这些病毒密切相关。通过动力学中和试验发现，所检测的两种病毒，即MHV-JHM和MHV-2，在抗原性上是不同的。发现MHV-3和MHV-A59在抗原性上非常相似但又有所不同。这些数据表明，动力学中和是确定鼠冠状病毒之间抗原关系的更精确方法。
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