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阿克拉霉素对红细胞ATP酶活性的抑制作用及抗坏血酸对ATP酶活性的逆转作用。

Inhibition of erythrocyte ATPase activity by aclacinomycin and reverse effects of ascorbate on ATPase activity.

作者信息

Kitao T, Hattori K

出版信息

Experientia. 1983 Dec 15;39(12):1362-4. doi: 10.1007/BF01990105.

DOI:10.1007/BF01990105
PMID:6317432
Abstract

We studied the effect of aclacinomycin on human erythrocyte membrane enzymes. Aclacinomycin inhibited ATPase, including Na-K-dependent ATPase, ouabain insensitive ATPase and Ca-ATPase. However acetylcholinesterase was not inhibited by aclacinomycin. The ATPase activities were not inhibited by aclacinomycin if ascorbate was added to the incubation mixture. However other reducing agents, alpha-tocopherol, superoxide dismutase and catalase had no effect on ATPase activity. Ascorbate may protect membrane proteins and lipids from peroxidate damage.

摘要

我们研究了阿克拉霉素对人红细胞膜酶的作用。阿克拉霉素抑制ATP酶，包括钠钾依赖性ATP酶、哇巴因不敏感ATP酶和钙ATP酶。然而，乙酰胆碱酯酶未被阿克拉霉素抑制。如果在孵育混合物中加入抗坏血酸，阿克拉霉素不会抑制ATP酶活性。然而，其他还原剂，如α-生育酚、超氧化物歧化酶和过氧化氢酶对ATP酶活性没有影响。抗坏血酸可能保护膜蛋白和脂质免受过氧化损伤。

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本文引用的文献

1
The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes.人红细胞无血红蛋白空泡的制备及其化学特性
Arch Biochem Biophys. 1963 Jan;100:119-30. doi: 10.1016/0003-9861(63)90042-0.
2
The effects of adriamycin (doxorubicin HCl) on human red blood cells.阿霉素（盐酸多柔比星）对人体红细胞的作用。
Hemoglobin. 1980;4(5-6):735-45. doi: 10.3109/03630268008997741.
3
International Committee for Standardization in Haematology: recommended methods for red-cell enzyme analysis.国际血液学标准化委员会：红细胞酶分析的推荐方法。
2型糖尿病患者红细胞钠钾ATP酶活性与糖尿病并发症之间的关系。
Endocrine. 2003 Aug;21(3):273-8. doi: 10.1385/ENDO:21:3:273.
4
Morpho-functional modifications of human syncytiotrophoblast plasma membrane during pregnancy induced hypertension.妊娠高血压疾病期间人合体滋养层细胞膜的形态功能改变
Mol Cell Biochem. 1995 Oct 4;151(1):15-20. doi: 10.1007/BF01076890.
Br J Haematol. 1977 Feb;35(2):331-40. doi: 10.1111/j.1365-2141.1977.tb00589.x.
4
Adriamycin and daunomycin generate reactive oxygen compounds in erythrocytes.阿霉素和柔红霉素可在红细胞中生成活性氧化合物。
Blood. 1978 Nov;52(5):878-85.
5
Clinical study of aclacinomycin A.阿克拉霉素A的临床研究。
Cancer Treat Rep. 1979 May;63(5):931-4.
6
Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin.阿霉素和柔红霉素的氧化还原循环产生自由基和脂质过氧化。
Biochem Biophys Res Commun. 1977 Jul 25;77(2):797-803. doi: 10.1016/s0006-291x(77)80048-x.