Henderson C A, Metz E N, Balcerzak S P, Sagone A L
Blood. 1978 Nov;52(5):878-85.
Adriamycin and daunomycin produce dose-related cardiac toxicity that may be related to oxygen radicals. Addition of these compounds to human erythrocyte suspensions resulted in stimulation of hexose monophosphate shunt activity that was markedly impaired in the absence of oxyhemoglobin. Evidence for generation of hydrogen peroxide by these compounds was provided by oxidation of reduced glutathione, by 14C-formate oxidation, and by the catalase-aminotriazole trapping technique. These experiments indicate that Adriamycin and daunomycin interact with oxyhemoglobin to generate reactive oxygen metabolites. A similar interaction with oxymyoglobin may occur in the heart and produce oxygen radicals that injure cardiac myocytes.
阿霉素和柔红霉素会产生与剂量相关的心脏毒性，这可能与氧自由基有关。将这些化合物添加到人体红细胞悬液中会导致磷酸己糖旁路活性增强，而在没有氧合血红蛋白的情况下这种活性会显著受损。这些化合物产生过氧化氢的证据来自还原型谷胱甘肽的氧化、14C-甲酸氧化以及过氧化氢酶-氨基三唑捕获技术。这些实验表明，阿霉素和柔红霉素与氧合血红蛋白相互作用以产生活性氧代谢产物。在心脏中可能会发生与氧合肌红蛋白的类似相互作用，并产生损伤心肌细胞的氧自由基。
