Ovcharov R G, Bantutova I I, Iosifov T I
Farmakol Toksikol. 1983 Nov-Dec;46(6):17-20.
Experiments on female rats have shown that gabalid (100 and 200 mg/kg) does not essentially change the formation of the conditioned reflexes in intact animals and in those with an involved caudate nucleus whereas cainic acid injected intraperitoneally (15 mg/kg) and applied to the caudate nucleus deteriorates and when given in a dose of 5 mg/kg improves the formation of the conditioned reflexes. Baclofen (10 mg/kg) inhibits the conditioned reflexes in both intact animals and in those with an involved caudate nucleus, whereas in a dose of 1 mg/kg the drug improves it in intact animals and inhibits it in animals with impaired function of the caudate nucleus. The importance of the GABA-ergic system of the caudate nucleus for the action of GABA-ergic agents on the conditioned reflexes in rats is discussed.
对雌性大鼠的实验表明，加巴喷丁（100和200毫克/千克）对未受损动物和尾状核受累动物的条件反射形成基本没有影响，而腹腔注射（15毫克/千克）并应用于尾状核的 kainic 酸会使条件反射形成恶化，当剂量为5毫克/千克时则会改善条件反射的形成。巴氯芬（10毫克/千克）在未受损动物和尾状核受累动物中均会抑制条件反射，而在剂量为1毫克/千克时，该药物在未受损动物中会改善条件反射，在尾状核功能受损的动物中则会抑制条件反射。文中讨论了尾状核的γ-氨基丁酸能系统对γ-氨基丁酸能药物对大鼠条件反射作用的重要性。
