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[γ-氨基丁酸能物质对大鼠条件性回避反应的影响]

[Effect of GABA-ergic substances on the conditioned avoidance reaction in rats].

作者信息

Raevskiĭ K S, Kharlamov A N

出版信息

Farmakol Toksikol. 1980 May-Jun;43(3):284-8.

PMID:7449967
Abstract

The effect of GABA-ergic substances on the production and latent period of the conditioned reflex of avoidance in rats has been studied. The inhibitor of GABA-transaminase n-dipropylacetate (depakin) deteriorates the reflex production. Fenibut and amino oxyacetic acid significantly prolong the latent period of the produced conditioned reflex of avoidance. The effect of amino oxyacetic acid on the conditioned reflex is abolished by bicuculline and is likely to be related to the increased brain GABA content.

摘要

研究了γ-氨基丁酸能物质对大鼠回避性条件反射的产生及潜伏期的影响。γ-氨基丁酸转氨酶抑制剂二丙基乙酸(德巴金)会使反射产生变差。芬氨比妥和氨氧乙酸显著延长所产生的回避性条件反射的潜伏期。氨氧乙酸对条件反射的作用被荷包牡丹碱消除,且可能与脑内γ-氨基丁酸含量增加有关。

相似文献

1
[Effect of GABA-ergic substances on the conditioned avoidance reaction in rats].[γ-氨基丁酸能物质对大鼠条件性回避反应的影响]
Farmakol Toksikol. 1980 May-Jun;43(3):284-8.
2
[The role of GABA-ergic transmission of caudate-putamen nucleus (CPN) in the control of conditioned behavior in rats].[尾状核-壳核(CPN)的γ-氨基丁酸能传递在大鼠条件性行为控制中的作用]
Sheng Li Xue Bao. 1991 Feb;43(1):8-13.
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[The action of neurotropin on the processes of conditioned-reflex avoidance in rats].[神经妥乐平对大鼠条件反射性回避过程的作用]
Zh Vyssh Nerv Deiat Im I P Pavlova. 1993 Mar-Apr;43(2):371-6.
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[Characteristics of the conditioned reaction of passive avoidance in rats after destruction of the terminal dopaminergic fields in the amygdaloid complex].
Zh Vyssh Nerv Deiat Im I P Pavlova. 1987 Nov-Dec;37(6):1070-4.
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[The intraventricular administration of quinolinic acid improves the formation of an active avoidance conditioned reflex in rats].[脑室内注射喹啉酸可改善大鼠主动回避条件反射的形成]
Zh Vyssh Nerv Deiat Im I P Pavlova. 1993 Nov-Dec;43(6):1234-6.
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[The interaction of the serotonin and dopaminergic systems of the brain in the mechanisms of latent inhibition in rats].
Zh Vyssh Nerv Deiat Im I P Pavlova. 1989 Jul-Aug;39(4):714-20.
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[Effect of activation and blocking of the GABA-ergic system during disorders of memory trace reproduction].[记忆痕迹再现障碍期间γ-氨基丁酸能系统激活与阻断的作用]
Zh Vyssh Nerv Deiat Im I P Pavlova. 1987 Jul-Aug;37(4):727-33.
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[Effect of GABA-ergic substances on the elaboration of conditioned reflexes in rats under negative reinforcement].[γ-氨基丁酸能物质对负强化条件下大鼠条件反射形成的影响]
Farmakol Toksikol. 1983 Nov-Dec;46(6):17-20.
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[The effect of alpha-tocopherol on conditioned reflex activity in adrenaline-induced myocardial dystrophy in rats].[α-生育酚对大鼠肾上腺素诱导的心肌营养不良中条件反射活动的影响]
Biull Eksp Biol Med. 1990 Mar;109(3):211-3.
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Differential effects of dopamine and AMPA receptor antagonists on the expression of conditioned avoidance responding in rats.多巴胺和AMPA受体拮抗剂对大鼠条件性回避反应表达的不同影响。
Behav Neurosci. 2008 Apr;122(2):377-84. doi: 10.1037/0735-7044.122.2.377.

引用本文的文献

1
Effect of activation and blockade of the GABAergic system on disturbance of memory trace reproduction.
Neurosci Behav Physiol. 1988 Jul-Aug;18(4):274-9. doi: 10.1007/BF01185516.