Bartoli G M, Müller A, Cadenas E, Sies H
FEBS Lett. 1983 Dec 12;164(2):371-4. doi: 10.1016/0014-5793(83)80319-6.
Different thiol-containing compounds, such as diethyldithiocarbamate (DDC), glutathione, penicillamine, and dithioerythritol have been chosen to study their effect on ascorbate/Fe-ADP-induced lipid peroxidation, detected by low-level chemiluminescence and alkane production. In the concentration range used, these thiols exerted a temporary protection against lipid peroxidation by lengthening the induction period; after overcoming this induction period, no substantial inhibition of either chemiluminescence or alkane production was observed. DDC was effective in protecting against lipid peroxidation in the nanomolar range, whereas the group of other thiol-containing molecules operated in the millimolar range.
已选用不同的含硫醇化合物，如二乙基二硫代氨基甲酸盐（DDC）、谷胱甘肽、青霉胺和二硫赤藓糖醇，来研究它们对通过低水平化学发光和烷烃生成检测的抗坏血酸/铁-ADP诱导的脂质过氧化的影响。在所使用的浓度范围内，这些硫醇通过延长诱导期对脂质过氧化起到了暂时的保护作用；在克服这个诱导期后，未观察到对化学发光或烷烃生成的实质性抑制。DDC在纳摩尔范围内对脂质过氧化具有保护作用，而其他含硫醇分子组则在毫摩尔范围内起作用。
