Coulton G R, Firth J A
Histochem J. 1983 Nov;15(11):1141-50. doi: 10.1007/BF01003977.
Parietal cells in the luminal segments of mouse gastric glands show high activity of acid-secreting potassium-dependent adenosine triphosphatase (H+, K+-ATPase) and of nicotinamide adenine dinucleotide-linked isocitrate dehydrogenase (NAD-ICDHase) and malate dehydrogenase (MDHase) but low activity of succinate dehydrogenase (SDHase). This pattern of activity is reversed in the basal segments of the same glands. These results and previous morphological findings support the conclusion that luminal segment parietal cells are much more active in hydrochloric acid secretion than those of the basal segment. The origin of this zonation may be either cellular deterioration with age or some more specific form of regulation of parietal cell metabolism.
小鼠胃腺管腔段的壁细胞显示出高活性的分泌酸的钾依赖性三磷酸腺苷酶（H⁺，K⁺-ATP酶）、烟酰胺腺嘌呤二核苷酸连接的异柠檬酸脱氢酶（NAD-ICDH酶）和苹果酸脱氢酶（MDH酶），但琥珀酸脱氢酶（SDH酶）活性较低。在同一腺管的基底段，这种活性模式则相反。这些结果以及先前的形态学发现支持这样的结论：管腔段壁细胞在盐酸分泌方面比基底段壁细胞活跃得多。这种分区的起源可能是随着年龄增长的细胞退化，或者是壁细胞代谢调控的某种更特殊形式。
